Modeling trajectories of regional volume loss in progressive supranuclear palsy.
Identifieur interne : 000909 ( Main/Exploration ); précédent : 000908; suivant : 000910Modeling trajectories of regional volume loss in progressive supranuclear palsy.
Auteurs : Keith A. Josephs [États-Unis] ; Rong Xia ; Jay Mandrekar ; Jeffrey L. Gunter ; Matthew L. Senjem ; Clifford R. Jack ; Jennifer L. WhitwellSource :
- Movement disorders : official journal of the Movement Disorder Society [ 1531-8257 ] ; 2013.
English descriptors
- KwdEn :
- Aged, Aged, 80 and over, Brain (pathology), Brain Mapping, Female, Humans, Image Processing, Computer-Assisted, Longitudinal Studies, Magnetic Resonance Imaging, Male, Middle Aged, Retrospective Studies, Supranuclear Palsy, Progressive (pathology), Supranuclear Palsy, Progressive (physiopathology), Time Factors.
- MESH :
- pathology : Brain, Supranuclear Palsy, Progressive.
- physiopathology : Supranuclear Palsy, Progressive.
- Aged, Aged, 80 and over, Brain Mapping, Female, Humans, Image Processing, Computer-Assisted, Longitudinal Studies, Magnetic Resonance Imaging, Male, Middle Aged, Retrospective Studies, Time Factors.
Abstract
Progressive supranuclear palsy is a neurodegenerative disease with progressive brain atrophy over time. It is unknown which specific brain regions decline over time, whether regional volume loss occurs in a linear fashion, and whether regional atrophy correlates with clinical decline over time in progressive supranuclear palsy. Twenty-eight subjects meeting probable progressive supranuclear palsy criteria were prospectively recruited and completed 96 MRI scans over 2 years. Mixed-effect models were utilized to determine which regions had significant atrophy over time and whether decline was linear or nonlinear. We assessed 13 regions across the brain, as well as whole-brain and ventricular volume. Regional trajectories were also correlated with change in clinical measures of executive function and gait and ocular motor impairment. A linear decline was observed in all frontal and temporal regions, the superior parietal lobe, the thalamus, the caudate nuclei, and the midbrain, as well as in the whole brain. Ventricular expansion was also linear. Nonlinear decline was observed for the caudal middle frontal lobe and globus pallidus. Rates of change in the superior frontal lobe, thalamus, and midbrain were beyond those expected in normal aging. Decline in frontal lobe volume and the midbrain area correlated best to decline in clinical measures. In progressive supranuclear palsy, atrophy is occurring in multiple brain regions, particularly in those that have previously been implicated in the disease. Decline is mainly linear but can be nonlinear for some regions. The frontal lobe and midbrain seem to be playing the most significant roles in the progressive worsening of clinical signs in progressive supranuclear palsy.
DOI: 10.1002/mds.25437
PubMed: 23568852
Affiliations:
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Josephs</name><affiliation wicri:level="1"><nlm:affiliation>Department of Neurology, Mayo Clinic, Rochester, Minnesota 55905, USA. josephs.keith@mayo.edu</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology, Mayo Clinic, Rochester, Minnesota 55905</wicri:regionArea><wicri:noRegion>Minnesota 55905</wicri:noRegion></affiliation></author><author><name sortKey="Xia, Rong" sort="Xia, Rong" uniqKey="Xia R" first="Rong" last="Xia">Rong Xia</name></author><author><name sortKey="Mandrekar, Jay" sort="Mandrekar, Jay" uniqKey="Mandrekar J" first="Jay" last="Mandrekar">Jay Mandrekar</name></author><author><name sortKey="Gunter, Jeffrey L" sort="Gunter, Jeffrey L" uniqKey="Gunter J" first="Jeffrey L" last="Gunter">Jeffrey L. Gunter</name></author><author><name sortKey="Senjem, Matthew L" sort="Senjem, Matthew L" uniqKey="Senjem M" first="Matthew L" last="Senjem">Matthew L. Senjem</name></author><author><name sortKey="Jack, Clifford R" sort="Jack, Clifford R" uniqKey="Jack C" first="Clifford R" last="Jack">Clifford R. Jack</name></author><author><name sortKey="Whitwell, Jennifer L" sort="Whitwell, Jennifer L" uniqKey="Whitwell J" first="Jennifer L" last="Whitwell">Jennifer L. Whitwell</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2013">2013</date><idno type="RBID">pubmed:23568852</idno><idno type="pmid">23568852</idno><idno type="doi">10.1002/mds.25437</idno><idno type="wicri:Area/PubMed/Corpus">000949</idno><idno type="wicri:Area/PubMed/Curation">000949</idno><idno type="wicri:Area/PubMed/Checkpoint">000924</idno><idno type="wicri:Area/Ncbi/Merge">003B32</idno><idno type="wicri:Area/Ncbi/Curation">003B32</idno><idno type="wicri:Area/Ncbi/Checkpoint">003B32</idno><idno type="wicri:Area/Main/Merge">000909</idno><idno type="wicri:Area/Main/Curation">000909</idno><idno type="wicri:Area/Main/Exploration">000909</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Modeling trajectories of regional volume loss in progressive supranuclear palsy.</title><author><name sortKey="Josephs, Keith A" sort="Josephs, Keith A" uniqKey="Josephs K" first="Keith A" last="Josephs">Keith A. Josephs</name><affiliation wicri:level="1"><nlm:affiliation>Department of Neurology, Mayo Clinic, Rochester, Minnesota 55905, USA. josephs.keith@mayo.edu</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology, Mayo Clinic, Rochester, Minnesota 55905</wicri:regionArea><wicri:noRegion>Minnesota 55905</wicri:noRegion></affiliation></author><author><name sortKey="Xia, Rong" sort="Xia, Rong" uniqKey="Xia R" first="Rong" last="Xia">Rong Xia</name></author><author><name sortKey="Mandrekar, Jay" sort="Mandrekar, Jay" uniqKey="Mandrekar J" first="Jay" last="Mandrekar">Jay Mandrekar</name></author><author><name sortKey="Gunter, Jeffrey L" sort="Gunter, Jeffrey L" uniqKey="Gunter J" first="Jeffrey L" last="Gunter">Jeffrey L. Gunter</name></author><author><name sortKey="Senjem, Matthew L" sort="Senjem, Matthew L" uniqKey="Senjem M" first="Matthew L" last="Senjem">Matthew L. Senjem</name></author><author><name sortKey="Jack, Clifford R" sort="Jack, Clifford R" uniqKey="Jack C" first="Clifford R" last="Jack">Clifford R. Jack</name></author><author><name sortKey="Whitwell, Jennifer L" sort="Whitwell, Jennifer L" uniqKey="Whitwell J" first="Jennifer L" last="Whitwell">Jennifer L. Whitwell</name></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="eISSN">1531-8257</idno><imprint><date when="2013" type="published">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Aged, 80 and over</term><term>Brain (pathology)</term><term>Brain Mapping</term><term>Female</term><term>Humans</term><term>Image Processing, Computer-Assisted</term><term>Longitudinal Studies</term><term>Magnetic Resonance Imaging</term><term>Male</term><term>Middle Aged</term><term>Retrospective Studies</term><term>Supranuclear Palsy, Progressive (pathology)</term><term>Supranuclear Palsy, Progressive (physiopathology)</term><term>Time Factors</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Brain</term><term>Supranuclear Palsy, Progressive</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Supranuclear Palsy, Progressive</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Aged, 80 and over</term><term>Brain Mapping</term><term>Female</term><term>Humans</term><term>Image Processing, Computer-Assisted</term><term>Longitudinal Studies</term><term>Magnetic Resonance Imaging</term><term>Male</term><term>Middle Aged</term><term>Retrospective Studies</term><term>Time Factors</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Progressive supranuclear palsy is a neurodegenerative disease with progressive brain atrophy over time. It is unknown which specific brain regions decline over time, whether regional volume loss occurs in a linear fashion, and whether regional atrophy correlates with clinical decline over time in progressive supranuclear palsy. Twenty-eight subjects meeting probable progressive supranuclear palsy criteria were prospectively recruited and completed 96 MRI scans over 2 years. Mixed-effect models were utilized to determine which regions had significant atrophy over time and whether decline was linear or nonlinear. We assessed 13 regions across the brain, as well as whole-brain and ventricular volume. Regional trajectories were also correlated with change in clinical measures of executive function and gait and ocular motor impairment. A linear decline was observed in all frontal and temporal regions, the superior parietal lobe, the thalamus, the caudate nuclei, and the midbrain, as well as in the whole brain. Ventricular expansion was also linear. Nonlinear decline was observed for the caudal middle frontal lobe and globus pallidus. Rates of change in the superior frontal lobe, thalamus, and midbrain were beyond those expected in normal aging. Decline in frontal lobe volume and the midbrain area correlated best to decline in clinical measures. In progressive supranuclear palsy, atrophy is occurring in multiple brain regions, particularly in those that have previously been implicated in the disease. Decline is mainly linear but can be nonlinear for some regions. The frontal lobe and midbrain seem to be playing the most significant roles in the progressive worsening of clinical signs in progressive supranuclear palsy.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country></list><tree><noCountry><name sortKey="Gunter, Jeffrey L" sort="Gunter, Jeffrey L" uniqKey="Gunter J" first="Jeffrey L" last="Gunter">Jeffrey L. Gunter</name><name sortKey="Jack, Clifford R" sort="Jack, Clifford R" uniqKey="Jack C" first="Clifford R" last="Jack">Clifford R. Jack</name><name sortKey="Mandrekar, Jay" sort="Mandrekar, Jay" uniqKey="Mandrekar J" first="Jay" last="Mandrekar">Jay Mandrekar</name><name sortKey="Senjem, Matthew L" sort="Senjem, Matthew L" uniqKey="Senjem M" first="Matthew L" last="Senjem">Matthew L. Senjem</name><name sortKey="Whitwell, Jennifer L" sort="Whitwell, Jennifer L" uniqKey="Whitwell J" first="Jennifer L" last="Whitwell">Jennifer L. Whitwell</name><name sortKey="Xia, Rong" sort="Xia, Rong" uniqKey="Xia R" first="Rong" last="Xia">Rong Xia</name></noCountry><country name="États-Unis"><noRegion><name sortKey="Josephs, Keith A" sort="Josephs, Keith A" uniqKey="Josephs K" first="Keith A" last="Josephs">Keith A. Josephs</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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